using poisson marginal models for investigating the effect of factors on interictal epileptiform discharge in patients with epilepsy

نویسندگان

mahsa saadati department of biostatistics, tarbiat modares university, tehran, iran

soghrat faghihzadeh department of biostatistics, tarbiat modares university, tehran, iran

sohrab hashemi fesharaki seizure department, shefa neuroscience research center, tehran, iran

marzieh gharakhani seizure department, shefa neuroscience research center, tehran, iran

چکیده

normal 0 false false false en-us x-none ar-sa microsoftinternetexplorer4 background: e pilepsy is a common, chronic neurological disorder that affects more than 40 million people worldwide. epilepsy is characterized by interictal and ictal functional disturbances. the presence of interictal epileptiform discharges (ieds) can help to confirm a clinical diagnosis of epilepsy, and their location and characteristics can help to identify the epileptogenic zone or suggest a particular epilepsy syndrome. the aim of this study is to determine the factors that affect ieds. materials and methods: p oisson marginal model was done on 60 epileptic patients who were referred to shefa neurological research center, tehran, for video-electroencephalogram (v-eeg) monitoring from 2007 to 2011. the frequency of ieds was assessed by visual analysis of interictal eeg samples for 2 h. results: t he results show that among age, epilepsy duration, gender, seizure frequency and two common anti-epileptic drugs (valproic acid and carbamazepine), only age and epilepsy duration had statistical significant effect on ied frequency. conclusion: i nvestigating the factors affecting ied is not only of theoretical importance, but may also have clinical relevance as understanding the evolution of interictal epileptogenesis may lead to the development of therapeutic interventions. generalized estimating equation is a valid statistical technique for studying factors that affect on ied. this research demonstrates epilepsy duration has positive and age has negative effect on ied which means that ied increases with epilepsy duration and decreases with increasing age. so for monitoring ied, we should consider both age and epilepsy duration of each patient.

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Using Poisson marginal models for investigating the effect of factors on interictal epileptiform discharge in patients with epilepsy

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عنوان ژورنال:
journal of research in medical sciences

جلد ۱۷، شماره ۹، صفحات ۰-۰

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